Blanton is a fictional town near the fictional campus of Fuchs College, which is the setting for the Nicole Tang Noonan mysteries.
The only reference to reality on this map is the note, "To Chillicothe," on the upper left. Thus, the town and campus are in the southeastern corner of Ohio.
Based on the history of the area as told in the first book of the series, Dark Mural, this part of Ohio was settled by immigrants from England in the early 1800s. They gave the creek an English name, Ware.
Although there really is a Ware Creek in Virginia, this fictional creek is in no way connected with it. Names of places were repeated all over the continental United States, the most famous example being "Springfield." There's one in every state.
As is typical of such towns, settlement began along the creek and spread outward. Buildings were erected wherever was convenient and paths worn between them. Later these paths were paved to make streets. As a result the town is not laid out on a strict grid pattern.
I have marked only places mentioned in the books so far. As you can see, there is a lot of unclaimed real estate in Blanton, but more books are on the way.